Injectable chitosan-based self-healing supramolecular hydrogels with temperature and pH dual-responsivenesses.
Int J Biol Macromol
; 227: 1038-1047, 2023 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-36460241
ABSTRACT
In this study, a supramolecular hydrogel was fabricated with orotic acid (OA) modified chitosan (OACS) and 2,6-diaminopurine (DAP). The obtained OACS-DAP supramolecular hydrogels have dual responsiveness to temperature and pH. Phase transition experiments indicate this is a temperature-dependent thermoreversible supramolecular hydrogel. Rheological experiments proved the formation of the supramolecular hydrogel and its thixotropic properties. FTIR spectra confirmed that hydrogen bonds and π-π interactions are the main driving forces for OACS and DAP to form hydrogels through intermolecular self-assembly. XRD pattern confirmed the amorphous morphology of OACS-DAP hydrogels. The hydrogel has excellent electrical conductivity with a conductivity of 9.48 µ S·cm-1. And can achieve the precise release of gastrointestinal drugs. OACS-DAP hydrogel is expected to have better applications in the field of gastrointestinal drug release.
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Hidrogéis
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Idioma:
En
Revista:
Int J Biol Macromol
Ano de publicação:
2023
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Article