Two new cytochalasins from the endophytic fungus <i>Xylaria</i> sp. GDGJ-77B.

Xu, Zhao-Long; Li, Ben-Chao; Huang, Li-Li; Lv, Liu-Xia; Luo, Yan; Xu, Wei-Feng; Yang, Rui-Yun

Two new cytochalasins from the endophytic fungus Xylaria sp. GDGJ-77B.

Xu, Zhao-Long; Li, Ben-Chao; Huang, Li-Li; Lv, Liu-Xia; Luo, Yan; Xu, Wei-Feng; Yang, Rui-Yun.

Afiliação

Xu ZL; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Collaborative Innovation Center for Guangxi Ethnic Medicine, Guangxi Normal University, Guilin, P. R. China.
Li BC; Guangxi Research Institute of Chemical Industry Co., Ltd., Nanning, P. R. China.
Huang LL; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Collaborative Innovation Center for Guangxi Ethnic Medicine, Guangxi Normal University, Guilin, P. R. China.
Lv LX; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Collaborative Innovation Center for Guangxi Ethnic Medicine, Guangxi Normal University, Guilin, P. R. China.
Luo Y; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Collaborative Innovation Center for Guangxi Ethnic Medicine, Guangxi Normal University, Guilin, P. R. China.
Xu WF; Life Sciences Institute, Guangxi Medical University, Nanning, P. R. China.
Yang RY; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Sciences, Collaborative Innovation Center for Guangxi Ethnic Medicine, Guangxi Normal University, Guilin, P. R. China.

Nat Prod Res ; : 1-7, 2022 Dec 05.

Article em En | MEDLINE | ID: mdl-36469678

ABSTRACT

ABSTRACT

Two new open-chain cytochalasins, xylarchalasins A and B (1 and 2), together with six known analogues (3-8), were isolated from the endophytic fungus Xylaria sp. GDGJ-77B from the Chinese medicinal plant Sophora tonkinensis. Their structures were elucidated on the basis of comprehensive spectroscopic analysis. Compound 2 displayed moderate antibacterial activities against Bacillus subtilis and Escherichia coli with MIC values of 25 and 12.5 µg/mL, respectively.

Palavras-chave

Xylaria sp.; antibacterial activities; cytochalasins; endophytic fungus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Nat Prod Res Ano de publicação: 2022 Tipo de documento: Article