FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT1A, 5-HT1B, and 5-HT1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 Knockout Mice.

Saraf, Tanishka S; McGlynn, Ryan P; Bhatavdekar, Omkar M; Booth, Raymond G; Canal, Clinton E

FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT_1A, 5-HT_1B, and 5-HT_1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 Knockout Mice.

Saraf, Tanishka S; McGlynn, Ryan P; Bhatavdekar, Omkar M; Booth, Raymond G; Canal, Clinton E.

Afiliação

Saraf TS; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, Georgia 30341, United States.
McGlynn RP; Center for Drug Discovery, Department of Pharmaceutical Sciences, and Department of Chemistry and Chemical Biology, Northeastern University, 300 Huntington Street, Boston, Massachusetts 02115, United States.
Bhatavdekar OM; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Croft Hall B27, Baltimore, Maryland 21218, United States.
Booth RG; Center for Drug Discovery, Department of Pharmaceutical Sciences, and Department of Chemistry and Chemical Biology, Northeastern University, 300 Huntington Street, Boston, Massachusetts 02115, United States.
Canal CE; Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, Georgia 30341, United States.

ACS Chem Neurosci ; 13(24): 3629-3640, 2022 12 21.

Article em En | MEDLINE | ID: mdl-36473166

Assuntos

Córtex Auditivo; Síndrome do Cromossomo X Frágil; Agonistas do Receptor 5-HT1 de Serotonina; Adulto; Animais; Feminino; Humanos; Masculino; Camundongos; Córtex Auditivo/metabolismo; Modelos Animais de Doenças; Eletroencefalografia; Proteína do X Frágil da Deficiência Intelectual/genética; Proteína do X Frágil da Deficiência Intelectual/metabolismo; Síndrome do Cromossomo X Frágil/tratamento farmacológico; Camundongos Knockout; Receptor 5-HT1D de Serotonina; Serotonina; Agonistas do Receptor 5-HT1 de Serotonina/farmacologia

Palavras-chave

5-HT1; EEG; Fmr1; alpha power; delta power; gamma power; serotonin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Auditivo / Agonistas do Receptor 5-HT1 de Serotonina / Síndrome do Cromossomo X Frágil Limite: Adult / Animals / Female / Humans / Male Idioma: En Revista: ACS Chem Neurosci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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