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Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Zhou, Jujun; Horton, John R; Menna, Martina; Fiorentino, Francesco; Ren, Ren; Yu, Dan; Hajian, Taraneh; Vedadi, Masoud; Mazzoccanti, Giulia; Ciogli, Alessia; Weinhold, Elmar; Hüben, Michael; Blumenthal, Robert M; Zhang, Xing; Mai, Antonello; Rotili, Dante; Cheng, Xiaodong.
Afiliação
  • Zhou J; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
  • Horton JR; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
  • Menna M; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Fiorentino F; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Ren R; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
  • Yu D; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
  • Hajian T; Structural Genomics Consortium, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Vedadi M; Structural Genomics Consortium, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Mazzoccanti G; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Ciogli A; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Weinhold E; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Hüben M; Institute of Organic Chemistry, RWTH Aachen University, D-52056 Aachen, Germany.
  • Blumenthal RM; Institute of Organic Chemistry, RWTH Aachen University, D-52056 Aachen, Germany.
  • Zhang X; Department of Medical Microbiology and Immunology, and Program in Bioinformatics, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614, United States.
  • Mai A; Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
  • Rotili D; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
  • Cheng X; Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
J Med Chem ; 66(1): 934-950, 2023 01 12.
Article em En | MEDLINE | ID: mdl-36581322
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Clostridioides difficile / Metiltransferases Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Clostridioides difficile / Metiltransferases Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos