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Triazole-based estradiol dimers prepared via CuAAC from 17α-ethinyl estradiol with five-atom linkers causing G2/M arrest and tubulin inhibition.
Jurásek, Michal; Rehulka, Jirí; Hrubá, Lenka; Ivanová, Aleksandra; Gurská, Sona; Mokshyna, Olena; Trousil, Pavel; Huml, Lukás; Polishchuk, Pavel; Hajdúch, Marián; Drasar, Pavel B; Dzubák, Petr.
Afiliação
  • Jurásek M; Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
  • Rehulka J; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital in Olomouc, Hnevotínská 1333/5, 779 00 Olomouc, Czech Republic.
  • Hrubá L; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital in Olomouc, Hnevotínská 1333/5, 779 00 Olomouc, Czech Republic.
  • Ivanová A; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital in Olomouc, Hnevotínská 1333/5, 779 00 Olomouc, Czech Republic.
  • Gurská S; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital in Olomouc, Hnevotínská 1333/5, 779 00 Olomouc, Czech Republic.
  • Mokshyna O; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital in Olomouc, Hnevotínská 1333/5, 779 00 Olomouc, Czech Republic.
  • Trousil P; Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
  • Huml L; Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
  • Polishchuk P; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital in Olomouc, Hnevotínská 1333/5, 779 00 Olomouc, Czech Republic.
  • Hajdúch M; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital in Olomouc, Hnevotínská 1333/5, 779 00 Olomouc, Czech Republic.
  • Drasar PB; Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague 6, Czech Republic.
  • Dzubák P; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University Hospital in Olomouc, Hnevotínská 1333/5, 779 00 Olomouc, Czech Republic. Electronic address: petr.dzubak@upol.cz.
Bioorg Chem ; 131: 106334, 2023 02.
Article em En | MEDLINE | ID: mdl-36592487
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis / Tubulina (Proteína) / Etinilestradiol / Moduladores de Tubulina / Antineoplásicos Idioma: En Revista: Bioorg Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: República Tcheca
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazóis / Tubulina (Proteína) / Etinilestradiol / Moduladores de Tubulina / Antineoplásicos Idioma: En Revista: Bioorg Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: República Tcheca