Association between prenatal androgens and cord blood androgens, a path analysis.
Sci Rep
; 13(1): 380, 2023 01 07.
Article
em En
| MEDLINE
| ID: mdl-36611054
ABSTRACT
To determine association paths between prenatal androgens and cord blood androgens. The concentrations of T, FT, DHT, DHEA and SHBG in prenatal venous blood and cord blood were measured in 342 pregnant women and their neonates. The association paths between these hormones in prenatal and cord blood were revealed using Pearson correlation, multiple linear regression and path analysis. CB-T, CB-FT and CB-DHT in male neonates were higher than those in female neonates. In male and female neonates, P-FT was lower than CB-FT; however, P-DHT and P-SHBG were higher than CB-DHT and CB-SHBG, respectively. P-DHEA was lower than CB-DHEA in female newborns. In male neonates, there were association paths of P-T â CB-T â CB-FT â CB-DHT, P-T â CB-FT â CB-DHT, P-T â P-FT â CB-FT â CB-DHT, P-T â P-DHT, CB-DHEA â CB-DHT, CB-DHEA â P-DHT, and CB-DHEA â P-DHEA. In female neonates, there were association paths of P-T â CB-T â CB-FT â CB-DHT, P-T â P-FT â CB-FT â CB-DHT, P-T â P-FT â P-DHT, P-T â P-DHT, P-DHEA â P-DHT, CB-DHEA â P-DHEA, and CB-DHEA â CB-FT. There were differences in the T, FT and DHT concentrations in cord blood between male and female neonates and in the FT, DHT, DHEA, and SHBG concentrations between prenatal and cord blood. P-T and P-FT concentrations were positively associated with CB-T and CB-FT concentrations, while CB-DHEA concentration was positively associated with P-DHEA concentration.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testosterona
/
Androgênios
Tipo de estudo:
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Sci Rep
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China