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Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages.
Tichet, Mélanie; Wullschleger, Stephan; Chryplewicz, Agnieszka; Fournier, Nadine; Marcone, Rachel; Kauzlaric, Annamaria; Homicsko, Krisztian; Deak, Laura Codarri; Umaña, Pablo; Klein, Christian; Hanahan, Douglas.
Afiliação
  • Tichet M; Swiss Institute for Experimental Cancer Research (ISREC), EPFL, Lausanne, Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland; Ludwig Institute for Cancer Research, Lausanne Branch, 1011 Lausanne, Switzerland; Agora Translational Cancer Research Center, Rue du Bugnon 25A, 1011 Lausa
  • Wullschleger S; Swiss Institute for Experimental Cancer Research (ISREC), EPFL, Lausanne, Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland. Electronic address: stephanw987@gmail.com.
  • Chryplewicz A; Swiss Institute for Experimental Cancer Research (ISREC), EPFL, Lausanne, Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland; Agora Translational Cancer Research Center, Rue du Bugnon 25A, 1011 Lausanne, Switzerland.
  • Fournier N; Bioinformatics Core Facility, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Marcone R; Bioinformatics Core Facility, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Kauzlaric A; Bioinformatics Core Facility, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Homicsko K; Swiss Institute for Experimental Cancer Research (ISREC), EPFL, Lausanne, Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland; Agora Translational Cancer Research Center, Rue du Bugnon 25A, 1011 Lausanne, Switzerland; Department of Oncology, CHUV, 46 Rue Bugnon, 1011 Lausanne, Switz
  • Deak LC; Roche-Innovation Center Zurich, 8952 Schlieren, Switzerland.
  • Umaña P; Roche-Innovation Center Zurich, 8952 Schlieren, Switzerland.
  • Klein C; Roche-Innovation Center Zurich, 8952 Schlieren, Switzerland.
  • Hanahan D; Swiss Institute for Experimental Cancer Research (ISREC), EPFL, Lausanne, Switzerland; Swiss Cancer Center Leman (SCCL), Lausanne, Switzerland; Ludwig Institute for Cancer Research, Lausanne Branch, 1011 Lausanne, Switzerland; Agora Translational Cancer Research Center, Rue du Bugnon 25A, 1011 Lausa
Immunity ; 56(1): 162-179.e6, 2023 01 10.
Article em En | MEDLINE | ID: mdl-36630914
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Imunoterapia / Macrófagos / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD8-Positivos / Imunoterapia / Macrófagos / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article