Impact of process stress on protein stability in highly-loaded solid protein/PEG formulations from small-scale melt extrusion.

Dauer, Katharina; Werner, Christian; Lindenblatt, Dirk; Wagner, Karl Gerhard

Dauer, Katharina; Werner, Christian; Lindenblatt, Dirk; Wagner, Karl Gerhard.

Afiliação

Dauer K; University of Bonn, Department of Pharmaceutics, Institute of Pharmacy, Bonn, Germany.
Werner C; University of Cologne, Department of Chemistry, Institute of Biochemistry, Cologne, Germany.
Lindenblatt D; University of Cologne, Department of Chemistry, Institute of Biochemistry, Cologne, Germany.
Wagner KG; University of Bonn, Department of Pharmaceutics, Institute of Pharmacy, Bonn, Germany.

Int J Pharm X ; 5: 100154, 2023 Dec.

Article em En | MEDLINE | ID: mdl-36632069

Palavras-chave

BSA, bovine serum albumin; BSE, backscattered electron; CD, circular dichroism; DSC, Differential Scanning Calorimetry; EDX, energy-dispersive X-ray detector; EVA, Ethylene-vinyl acetate; FTIR, Fourier transformation infrared spectroscopy; HME, hot-melt extrusion; HMWS, high molecular weight species; Hot-melt extrusion; PEG, polyethylene glycol; PEO, polyethylene oxide; PLGA, Poly Lactic-co-Glycolic Acid; Protein stability; SEM, scanning electron microscopy; Small-scale; Solid-state characterization; TSE, twin-screw extrusion; ss, solid-state

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Int J Pharm X Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha

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