4Methoxydalbergione inhibits esophageal carcinoma cell proliferation and migration by inactivating NFκB.
Oncol Rep
; 49(2)2023 02.
Article
em En
| MEDLINE
| ID: mdl-36633144
ABSTRACT
4Methoxydalbergione (4MD) can inhibit the progression of certain types of cancer; however, its effects on esophageal cancer (EC) remain unclear. The present study aimed to investigate the inhibitory effect of 4MD on EC and its molecular mechanism. ECA109 and KYSE105 cells were treated with or without lipopolysaccharide (LPS) and 4MD. Cell Counting Kit8 and colony formation assays were used to analyze cell proliferation. Wound healing assay was performed to evaluate cell migration. ELISA and western blotting were performed to measure the expression levels of NFκB and inflammatory cytokines. In cells treated with 4MD, proliferation and migration were significantly inhibited, the levels of inflammatory cytokines were downregulated and the NFκB signaling pathway was inactivated. Notably, proliferation, migration, inflammation and NFκB were promoted by LPS, whereas 4MD reversed the increases induced by LPS in EC cells. In conclusion, 4MD may attenuate the proliferation and migration of EC cells by inactivating the NFκB signaling pathway.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Esofágicas
/
Benzoquinonas
/
NF-kappa B
Limite:
Humans
Idioma:
En
Revista:
Oncol Rep
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2023
Tipo de documento:
Article