Emerging Biomarkers in Alcohol-associated Hepatitis.
J Clin Exp Hepatol
; 13(1): 103-115, 2023.
Article
em En
| MEDLINE
| ID: mdl-36647419
ABSTRACT
Alcohol-associated hepatitis (AH) is a clinical syndrome of jaundice, abdominal pain, and anorexia due to prolonged heavy alcohol intake. AH is associated with changes in gene expression, cytokines, immune response, and the gut microbiome. There are limited biomarkers to diagnose and prognosticate in AH, but several non-invasive biomarkers are emerging. In this review, clinical risk-stratifying algorithms, promising AH biomarkers like cytokeratin-18 fragments, genetic polymorphisms, and microRNAs will be reviewed.
AH, Alcohol-associated hepatitis; ALD, alcohol-associated liver disease; ASCA, antiSaccharomyces cerevisiae antibodies; AUC, area under the curve; FGF, fibroblast growth factor; GAHS, Glasgow alcohol-associated hepatitis score; HCC, hepatocellular carcinoma; MELD, model for end-stage liver disease; NASH, non-alcohol-associated steatohepatitis; PPV, positive predictive value; PT, prothrombin time; VCTE, vibration-controlled transient elastography; alcohol-associated hepatitis; biomarkers; cytokines; miRNAs, MicroRNAs; microRNA; microbiome
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
Problema de saúde:
2_enfermedades_transmissibles
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Clin Exp Hepatol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos
