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Non-Omicron breakthrough infection with higher viral load and longer vaccination-infection interval improves SARS-CoV-2 BA.4/5 neutralization.
Miyamoto, Sho; Arashiro, Takeshi; Ueno, Akira; Kanno, Takayuki; Saito, Shinji; Katano, Harutaka; Iida, Shun; Ainai, Akira; Ozono, Seiya; Hemmi, Takuya; Hirata, Yuichiro; Moriyama, Saya; Kotaki, Ryutaro; Kinoshita, Hitomi; Yamada, Souichi; Shinkai, Masaharu; Fukushi, Shuetsu; Takahashi, Yoshimasa; Suzuki, Tadaki.
Afiliação
  • Miyamoto S; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Arashiro T; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Ueno A; Center for Surveillance Immunization and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Kanno T; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Saito S; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Katano H; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Iida S; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Ainai A; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Ozono S; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Hemmi T; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Hirata Y; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Moriyama S; Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Kotaki R; Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Kinoshita H; Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Yamada S; Department of Virology I, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Shinkai M; Department of Virology I, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Fukushi S; Tokyo Shinagawa Hospital, Tokyo 140-8522, Japan.
  • Takahashi Y; Department of Virology I, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
  • Suzuki T; Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
iScience ; 26(2): 105969, 2023 Feb 17.
Article em En | MEDLINE | ID: mdl-36687316
ABSTRACT
The immune responses to SARS-CoV-2 variants in COVID-19 cases are influenced by various factors including pre-existing immunity via vaccination and prior infection. Elucidating the drivers for upgrading neutralizing activity to SARS-CoV-2 in COVID-19 cases with pre-existing immunity will aid in improving COVID-19 booster vaccines with enhanced cross-protection against antigenically distinct variants, including the Omicron sub-lineage BA.4/5. This study revealed that the magnitude and breadth of neutralization activity to SARS-CoV-2 variants after breakthrough infections are determined primarily by upper respiratory viral load and vaccination-infection time interval. Extensive neutralizing breadth, covering even the most antigenically distant BA.4/5, was observed in cases with higher viral load and longer time intervals. Antigenic cartography depicted a critical role of the time interval in expanding the breadth of neutralization to SARS-CoV-2 variants. Our results illustrate the importance of dosing interval optimization as well as antigen design in developing variant-proof booster vaccines.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: IScience Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: IScience Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão