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Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance.
Salta, Evgenia; Lazarov, Orly; Fitzsimons, Carlos P; Tanzi, Rudolph; Lucassen, Paul J; Choi, Se Hoon.
Afiliação
  • Salta E; Laboratory of Neurogenesis and Neurodegeneration, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands.
  • Lazarov O; Department of Anatomy and Cell Biology, College of Medicine, The University of Illinois at Chicago, 808 S Wood St., Chicago, IL 60612, USA.
  • Fitzsimons CP; Brain Plasticity group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands.
  • Tanzi R; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, McCance Center for Brain Health, 114 16th Street, Boston, MA 02129, USA. Electronic address: tanzi@helix.mgh.harvard.edu.
  • Lucassen PJ; Brain Plasticity group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Science Park 904, 1098 XH, Amsterdam, The Netherlands; Center for Urban Mental Health, University of Amsterdam, Kruislaan 404, 1098 SM, Amsterdam, The Netherlands. Electronic address: p.j.luc
  • Choi SH; Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, McCance Center for Brain Health, 114 16th Street, Boston, MA 02129, USA. Electronic address: choi.sehoon@mgh.harvard.edu.
Cell Stem Cell ; 30(2): 120-136, 2023 02 02.
Article em En | MEDLINE | ID: mdl-36736288
ABSTRACT
Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients. Understanding AHN regulation in AD could provide a framework for innovative pharmacological interventions. We here combine molecular, behavioral, and clinical data and critically discuss the multicellular complexity of the AHN niche in relation to AD pathophysiology. We further present a roadmap toward a better understanding of the role of AHN in AD by probing the promises and caveats of the latest technological advancements in the field and addressing the conceptual and methodological challenges ahead.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Adult / Humans Idioma: En Revista: Cell Stem Cell Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Adult / Humans Idioma: En Revista: Cell Stem Cell Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Holanda