Pregnancy outcomes in patients with Budd-Chiari syndrome: A tertiary care experience.
Indian J Gastroenterol
; 42(1): 96-105, 2023 02.
Article
em En
| MEDLINE
| ID: mdl-36738382
ABSTRACT
BACKGROUND:
Budd-Chiari syndrome (BCS) is associated with infertility and adverse pregnancy outcomes in affected females. Scant literature is available on the effect of an endovascular intervention on fertility and the outcome of future pregnancies in these patients.AIMS:
To assess the infertility rates, maternal and fetal outcomes of pregnancy and effect of endovascular intervention in women with BCS.METHODS:
In this retrospective analysis, 121 female patients with BCS attending our liver clinic from 2017 to 2020 were included. Demographic details, intervention details, pregnancies - pre- and post-intervention - and fetal outcomes were noted.RESULTS:
BCS was diagnosed pre-conception in 58 women (group 1; median age 22 years), during/after pregnancy, but before completion of family in 39 (group 2; median age 27 years), and after completion of family in 24 (group 3; median age 34 years). Median Child-Turcotte-Pugh (CTP) and model for end-stage liver disease (MELD) scores were 7 and 12, respectively. The primary infertility rate was 19.8% (24/121). In group 1, 15 women with primary infertility underwent endovascular intervention with 5/15 (33%) women conceiving subsequently, resulting in four live births and seven abortions. In group 2, five women developed BCS during pregnancy and 11 postpartum; 11/39 had a history of one or more abortions. Overall, 8/34 (23.5%) who underwent endovascular intervention had 4/8 (50%) successful pregnancies. In group 3, no patient had any major complications during past pregnancies. The mode of delivery was vaginal in 88% of cases. No congenital anomaly/major bleeding episodes/decompensation/maternal mortality occurred.CONCLUSIONS:
Infertility is common in patients with BCS. Pregnancy is well-tolerated in those with compensated liver disease.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Problema de saúde:
2_mortalidade_materna
/
2_muertes_prevenibles
/
6_cardiovascular_diseases
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6_digestive_diseases
/
7_non_communicable_diseases
Assunto principal:
Doença Hepática Terminal
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Síndrome de Budd-Chiari
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Infertilidade
Tipo de estudo:
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Pregnancy
Idioma:
En
Revista:
Indian J Gastroenterol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Índia