T cells engineered with full-length NKG2D linked to signaling domains of 4-1BB and CD3Î¶ show enhanced antitumor activity.

Teng, Xia; Rong, Zhuona; Li, Shance; Yang, Wenjun; Lu, Zheming

Teng, Xia; Rong, Zhuona; Li, Shance; Yang, Wenjun; Lu, Zheming.

Afiliação

Teng X; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing, China.
Rong Z; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing, China.
Li S; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing, China.
Yang W; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing, China.
Lu Z; Ningxia Human Stem Cell Research Institute, The General Hospital of Ningxia Medical University, Yinchuan, China.

Immunol Cell Biol ; 101(5): 458-464, 2023 05.

Article em En | MEDLINE | ID: mdl-36811384

Assuntos

Neoplasias; Linfócitos T; Humanos; Linhagem Celular Tumoral; Imunoterapia; Imunoterapia Adotiva; Subfamília K de Receptores Semelhantes a Lectina de Células NK; Transdução de Sinais; Ensaios Antitumorais Modelo de Xenoenxerto; Ligante 4-1BB/metabolismo

Palavras-chave

4-1BB; CAR-T; NKG2D; lung cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Immunol Cell Biol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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