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A dual-amplified ROS-responsive nanosystem with self-accelerating drug release for synergistic chemotherapy.
Li, Jun; Zong, Qingyu; Zhao, Zhongyi; Yuan, Youyong.
Afiliação
  • Li J; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, P. R. China. yuanyy@scut.edu.cn.
  • Zong Q; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, P. R. China.
  • Zhao Z; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510006, P. R. China.
  • Yuan Y; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, P. R. China.
Chem Commun (Camb) ; 59(21): 3142-3145, 2023 Mar 09.
Article em En | MEDLINE | ID: mdl-36811610
ABSTRACT
In this work, we have developed a tumor-specific self-accelerating prodrug activation nanosystem consisting of self-amplifying degradable polyprodrug PEG-TA-CA-DOX and encapsulated fluorescent prodrug BCyNH2, equipped with a reactive oxygen species dual-cycle amplification effect. Furthermore, activated CyNH2 is a therapeutic agent with potential to synergistically improve chemotherapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Nanopartículas Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Nanopartículas Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article