Ethnic disparities in ambient air and traffic-related pollution exposure and ethnic-specific impacts on clinical biomarker levels.
Sci Total Environ
; 873: 162390, 2023 May 15.
Article
em En
| MEDLINE
| ID: mdl-36841400
ABSTRACT
BACKGROUND:
Although characterizing the inequality in pollution exposure burden across ethnic groups and the ethnic-specific exposure associations is of great social and public health importance, it has not been systematically investigated in large population studies.METHODS:
The UK Biobank data (N = 485, 806) of individual-level air ambient and traffic-related pollution exposure, biomarkers routinely used in clinical practice, genotype, life-style factors, and socioeconomic status were analyzed. Air pollution exposure estimates were compared among six genetically inferred ethnic groups. We also quantified the association between exposure and biomarkers within and across ethnicities.RESULTS:
Non-European participants (defined by genetics) disproportionately bear a higher burden of exposure than their European counterparts even after adjusting for covariables including socioeconomic status. For example, exposure to NO2 in people with African ancestry was 30.7 % higher (p = 1.5E-786) than European subjects. Within the genetically defined African group, larger African genetic ancestry proportion (AGAP) was linked to higher ambient air pollutant exposure. Trans-Ethnic analysis identified 32 clinical biomarkers associated with environmental exposure. For 13 biomarkers, the association with exposure was significantly different or even in opposing directions across ethnic groups.CONCLUSIONS:
Substantial disparities in air pollution exposure was observed among genetically-defined ethnic groups. Most importantly, we show that the impact of exposure on biomarkers varies by ethnicity. Reducing the disproportionally high exposure burden on non-European populations and alleviating the adverse consequences in an ethnic-specific manner are of great urgency and significance.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
Problema de saúde:
1_desigualdade_iniquidade
/
2_cobertura_universal
/
2_quimicos_contaminacion
Assunto principal:
Poluentes Atmosféricos
/
Poluição do Ar
/
Poluição Relacionada com o Tráfego
Tipo de estudo:
Prognostic_studies
Aspecto:
Equity_inequality
Limite:
Humans
Idioma:
En
Revista:
Sci Total Environ
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China