Serum exosomes derived from spontaneously hypertensive rats induce cardiac hypertrophy in vitro and in vivo by increasing autocrine release of angiotensin II in cardiomyocytes.

Yu, Jingwei; Tang, Yuan; Wang, Yu; Zhou, Mi; Li, Yanwen; Hong, Jiahuan; Li, Chunmei; Xu, Bin; Guo, Xinmin; Mao, Jianwen

Yu, Jingwei; Tang, Yuan; Wang, Yu; Zhou, Mi; Li, Yanwen; Hong, Jiahuan; Li, Chunmei; Xu, Bin; Guo, Xinmin; Mao, Jianwen.

Afiliação

Yu J; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances and School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China; These authors contributed equally to this work.
Tang Y; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances and School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China; These authors contributed equally to this work.
Wang Y; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances and School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China; These authors contributed equally to this work.
Zhou M; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances and School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China; These authors contributed equally to this work.
Li Y; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances and School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Hong J; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances and School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Li C; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances and School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Xu B; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances and School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Guo X; Department of Ultrasound, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, China. Electronic address: guo8186@126.com.
Mao J; Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances and School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: jianwenmao@gdpu.edu.cn.

Biochem Pharmacol ; 210: 115462, 2023 04.

Article em En | MEDLINE | ID: mdl-36849061

Assuntos

Exossomos; Hipertensão; Ratos; Camundongos; Animais; Angiotensina II/metabolismo; Ratos Endogâmicos SHR; Miócitos Cardíacos/metabolismo; Renina/metabolismo; Exossomos/metabolismo; Camundongos Endogâmicos C57BL; Cardiomegalia/induzido quimicamente; Cardiomegalia/metabolismo; Sistema Renina-Angiotensina; Hipertensão/metabolismo

Palavras-chave

Angiotensin II; Cardiac hypertrophy; Exosome; Hypertension

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Exossomos / Hipertensão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biochem Pharmacol Ano de publicação: 2023 Tipo de documento: Article

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