Performance of two-dimensional shear wave elastography and transient elastography compared to liver biopsy for staging of liver fibrosis.
Eur J Clin Invest
; 53(7): e13980, 2023 Jul.
Article
em En
| MEDLINE
| ID: mdl-36880934
ABSTRACT
BACKGROUND:
Staging of liver fibrosis traditionally relied on liver histology; however, transient elastography (TE) and more recently two-dimensional shear wave elastography (2D-SWE) evolved to noninvasive alternatives. Hence, we evaluated the diagnostic accuracy of 2D-SWE assessed by the Canon Aplio i800 ultrasound system using liver biopsy as reference and compared the performance to TE.METHODS:
In total, 108 adult patients with chronic liver disease undergoing liver biopsy, 2D-SWE and TE were enrolled prospectively at the University Hospital Zurich. Diagnostic accuracies were evaluated using the area under the receiver operating characteristic (AUROC) analysis, and optimal cut-off values by Youden's index.RESULTS:
Diagnostic accuracy of 2D-SWE was good for significant (≥F2; AUROC 85.2%, 95% confidence interval (95%CI)76.2-91.2%) as well as severe fibrosis (≥F3; AUROC 86.8%, 95%CI 78.1-92.4%) and excellent for cirrhosis (AUROC 95.6%, 95%CI 89.9-98.1%), compared to histology. TE performed equally well (significant fibrosis 87.5%, 95%CI 77.7-93.3%; severe fibrosis 89.7%, 95%CI 82.0-94.3%; cirrhosis 96%, 95%CI 90.4-98.4%), and accuracy was not statistically different to 2D-SWE. 2D-SWE optimal cut-off values were 6.5, 9.8 and 13.1 kPa for significant fibrosis, severe fibrosis and cirrhosis, respectively.CONCLUSIONS:
Performance of 2D-SWE was good to excellent and well comparable with TE, supporting the application of this 2D-SWE system in the diagnostic workup of chronic liver disease.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Técnicas de Imagem por Elasticidade
/
Hepatopatias
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Eur J Clin Invest
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Suíça