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Fumarate induces vesicular release of mtDNA to drive innate immunity.
Zecchini, Vincent; Paupe, Vincent; Herranz-Montoya, Irene; Janssen, Joëlle; Wortel, Inge M N; Morris, Jordan L; Ferguson, Ashley; Chowdury, Suvagata Roy; Segarra-Mondejar, Marc; Costa, Ana S H; Pereira, Gonçalo C; Tronci, Laura; Young, Timothy; Nikitopoulou, Efterpi; Yang, Ming; Bihary, Dóra; Caicci, Federico; Nagashima, Shun; Speed, Alyson; Bokea, Kalliopi; Baig, Zara; Samarajiwa, Shamith; Tran, Maxine; Mitchell, Thomas; Johnson, Mark; Prudent, Julien; Frezza, Christian.
Afiliação
  • Zecchini V; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
  • Paupe V; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
  • Herranz-Montoya I; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
  • Janssen J; Molecular Oncology Programme, Growth Factors, Nutrients and Cancer Group Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.
  • Wortel IMN; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
  • Morris JL; Human and Animal Physiology, Wageningen University and Research, Wageningen, The Netherlands.
  • Ferguson A; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
  • Chowdury SR; Department of Data Science, Institute for Computing and Information Sciences, Radboud University, Nijmegen, The Netherlands.
  • Segarra-Mondejar M; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
  • Costa ASH; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
  • Pereira GC; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
  • Tronci L; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
  • Young T; CECAD Research Centre, University of Cologne, Cologne, Germany.
  • Nikitopoulou E; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
  • Yang M; Matterworks, Somerville, MA, USA.
  • Bihary D; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
  • Caicci F; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
  • Nagashima S; Cogentech SRL Benefit Corporation, Milan, Italy.
  • Speed A; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
  • Bokea K; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
  • Baig Z; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
  • Samarajiwa S; CECAD Research Centre, University of Cologne, Cologne, Germany.
  • Tran M; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, UK.
  • Mitchell T; VIB KU Leuven Center for Cancer Biology, Leuven, Belgium.
  • Johnson M; Department of Biology, University of Padova, Padova, Italy.
  • Prudent J; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.
  • Frezza C; Laboratory of Regenerative Medicine, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Nature ; 615(7952): 499-506, 2023 03.
Article em En | MEDLINE | ID: mdl-36890229
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Fumaratos / Imunidade Inata / Mitocôndrias Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Fumaratos / Imunidade Inata / Mitocôndrias Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido