Retinopathy of prematurity and placental histopathology findings: A retrospective cohort study.
Front Pediatr
; 11: 1099614, 2023.
Article
em En
| MEDLINE
| ID: mdl-36911032
ABSTRACT
Aim:
Retinopathy of prematurity (ROP) is a biphasic vaso-proliferative disease that has the potential to cause blindness. In addition to prematurity and hyperoxia, perinatal infection and inflammation have been reported to play a critical role in the pathogenesis of ROP. The aim of this study was to assess the association between placental inflammation and the severity of ROP.Methods:
A retrospective study of infants (<30 weeks of gestational age) born at the King Edward Memorial Hospital, a tertiary perinatal center in Western Australia.Results:
A total of 878 infants were included in this study (ROP stage 0-2 = 829; 3 or more = 49). The presence of maternal chorioamnionitis appeared to show signs of an association with reduced odds of severe ROP mild chorioamnionitis OR=0.43 (95% CI 0.17, 1.05) and severe chorioamnionitis OR=0.68 (95% CI 0.29, 1.60). A strong association was observed for oxygen supplementation at 36 weeks (OR 5.16; p < 0.001), exposure to postnatal steroids (OR 6.65; p < 0.001), and receipt of platelet transfusion (OR 8.21; p < 0.001).Conclusion:
Maternal chorioamnionitis or fetal chorioamnionitis was associated with reduced odds of severe ROP. A strong association was found in infants who needed oxygen supplementation at 36 weeks and those who required steroids or platelets in the postnatal period.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Front Pediatr
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Austrália