Clearance as an Early Indicator of Efficacy for Therapeutic Monoclonal Antibodies: Circumventing Dose Selection Challenges in Oncology.

Chen, Chengcong; Fan, Xiaoqing; Zhang, Lin; Xu, Peng; Zou, Huixi; Zhao, Xing; Gupta, Manish; Feng, Yan Summer; Xu, Xu Steven; Yan, Xiaoyu

Chen, Chengcong; Fan, Xiaoqing; Zhang, Lin; Xu, Peng; Zou, Huixi; Zhao, Xing; Gupta, Manish; Feng, Yan Summer; Xu, Xu Steven; Yan, Xiaoyu.

Afiliação

Chen C; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.
Fan X; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.
Zhang L; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.
Xu P; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.
Zou H; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.
Zhao X; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.
Gupta M; Clinical Pharmacology and Quantitative Science, Genmab Inc., Princeton, NJ, USA.
Feng YS; Clinical Pharmacology and Quantitative Science, Genmab Inc., Princeton, NJ, USA.
Xu XS; Clinical Pharmacology and Quantitative Science, Genmab Inc., Princeton, NJ, USA. sxu@genmab.com.
Yan X; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR. xiaoyuyan@cuhk.edu.hk.

Clin Pharmacokinet ; 62(5): 705-713, 2023 05.

Article em En | MEDLINE | ID: mdl-36930421

Assuntos

Anticorpos Monoclonais; Neoplasias; Humanos; Anticorpos Monoclonais/uso terapêutico; Neoplasias/tratamento farmacológico; Meia-Vida; Biomarcadores Tumorais

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Monoclonais / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Clin Pharmacokinet Ano de publicação: 2023 Tipo de documento: Article

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