Design of a new method for one-pot synthesis of 2-amino thiazoles using trichloroisocyanuric acid in the presence of a novel multi-functional and magnetically catalytic nanosystem: Ca/4-MePy-IL@ZY-Fe3O4.

ABSTRACT

In this study, an effective approach was developed to synthesize a novel, multifunctional ionic liquid nanocatalyst based on zeolite-Y with 4-methylpyridinium chloride (4-MePy-Cl) and calcium ions (Ca/4-MePy-IL@ZY). Then, Fe3O4 nanoparticles were produced inside the zeolite pores with the use of ultrasonic waves. XRD, FESEM, FT-IR, EDX-Map, TGA-DTA, VSM, BET, and atomic absorption techniques were used to identify the structure of the magnetic nanocomposite. Then, its catalytic activity in the one-pot synthesis of 2-aminothiazoles using trichloroisocyanuric acid (TCCA) as a green supplier of halogen ions for intermediates was studied. To provide ideal conditions for the preparation of pure products, first, the one-pot reaction of acetophenone and thiourea in various solvents, different temperatures, and the presence of different amounts of nanocatalysts and the molar amount of TCCA was used. Next, the reaction was investigated in the one-pot preparation of 2-aminothiazole derivatives under optimal conditions. This method replaces iodine (I2), a toxic reagent, for the first time with TCCA, a safe and sustainable source of halogen. The use of non-toxic solvent and a cheap, safe, recyclable nanocatalyst, quick reaction times, high efficiency, and ease of nanocatalyst separation with the aid of a magnet are additional benefits of this method. This has led to this procedure being classified as "green chemistry".