Pyrazole-Enriched Cationic Nanoparticles Induced Early- and Late-Stage Apoptosis in Neuroblastoma Cells at Sub-Micromolar Concentrations.

Zuccari, Guendalina; Zorzoli, Alessia; Marimpietri, Danilo; Brullo, Chiara; Alfei, Silvana

Zuccari, Guendalina; Zorzoli, Alessia; Marimpietri, Danilo; Brullo, Chiara; Alfei, Silvana.

Afiliação

Zuccari G; Department of Pharmacy, Section of Chemistry and Pharmaceutical and Food Technologies, University of Genoa, Viale Cembrano, 4, 16148 Genoa, Italy.
Zorzoli A; Cell Factory, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genoa, Italy.
Marimpietri D; Cell Factory, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147 Genoa, Italy.
Brullo C; Department of Pharmacy (DIFAR), Section of Medicinal Chemistry and Cosmetic Product, University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
Alfei S; Department of Pharmacy, Section of Chemistry and Pharmaceutical and Food Technologies, University of Genoa, Viale Cembrano, 4, 16148 Genoa, Italy.

Pharmaceuticals (Basel) ; 16(3)2023 Mar 05.

Article em En | MEDLINE | ID: mdl-36986492

Palavras-chave

4-AAD necrosis detection; Annexin-V apoptosis detection; cationic macromolecules; dose- and time-dependent cytotoxicity studies; membrane disruptors; neuroblastoma; pyrazoles-based cationic nanoparticles; selectivity index

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharmaceuticals (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália

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