Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells.

Sbirkov, Y; Schenk, T; Kwok, C; Stengel, S; Brown, R; Brown, G; Chesler, L; Zelent, A; Fuchter, M J; Petrie, K

Sbirkov, Y; Schenk, T; Kwok, C; Stengel, S; Brown, R; Brown, G; Chesler, L; Zelent, A; Fuchter, M J; Petrie, K.

Afiliação

Sbirkov Y; Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom.
Schenk T; Department of Medical Biology, Medical University of Plovdiv, Plovdiv, Bulgaria.
Kwok C; Research Institute at Medical University of Plovdiv, Plovdiv, Bulgaria.
Stengel S; Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom.
Brown R; Department of Hematology and Medical Oncology, Clinic of Internal Medicine II, Jena University Hospital, Jena, Germany.
Brown G; Institute of Molecular Cell Biology, CMB, Jena University Hospital, Jena, Germany.
Chesler L; Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom.
Zelent A; Division of Clinical Studies, The Institute of Cancer Research, London, United Kingdom.
Fuchter MJ; Division of Gastroenterology, Hepatology and Infectious Diseases, Department of Internal Medicine IV, Jena University Hospital, Jena, Germany.
Petrie K; Department of Surgery and Cancer, Imperial College London, London, United Kingdom.

Front Cell Dev Biol ; 11: 1076458, 2023.

Article em En | MEDLINE | ID: mdl-37035245

Palavras-chave

EZH2/KMT6A; G9A/EHMT2; GLP/EHMT1; HKMTI-1-005; RARα; acute myeloid leukemia (AML); all-trans retinoic acid (ATRA); differentiation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Cell Dev Biol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido

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