Anticancer Effects of Gut Microbiota-Derived Short-Chain Fatty Acids in Cancers.
J Microbiol Biotechnol
; 33(7): 849-856, 2023 Jul 28.
Article
em En
| MEDLINE
| ID: mdl-37100764
ABSTRACT
Short-chain fatty acids (SCFAs), such as butyrate, propionate, and acetate produced by the gut microbiota have been implicated in physiological responses (defense mechanisms, immune responses, and cell metabolism) in the human body. In several types of cancers, SCFAs, especially butyrate, suppress tumor growth and cancer cell metastasis via the regulation of the cell cycle, autophagy, cancer-related signaling pathways, and cancer cell metabolism. In addition, combination treatment with SCFAs and anticancer drugs exhibits synergistic effects, increasing anticancer treatment efficiency and attenuating anticancer drug resistance. Therefore, in this review, we point out the importance of SCFAs and the mechanisms underlying their effects in cancer treatment and suggest using SCFA-producing microbes and SCFAs to increase therapeutic efficacy in several types of cancers.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
3_ND
Problema de saúde:
3_zoonosis
Assunto principal:
Microbioma Gastrointestinal
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
J Microbiol Biotechnol
Ano de publicação:
2023
Tipo de documento:
Article