5-ALA treatment increases intracellular heme levels and enhances CYP3A4 activity in genome-edited Caco-2 cells.

Watanabe, Keita; Negoro, Ryosuke; Fujita, Takuya

5-ALA treatment increases intracellular heme levels and enhances CYP3A4 activity in genome-edited Caco-2 cells.

Watanabe, Keita; Negoro, Ryosuke; Fujita, Takuya.

Afiliação

Watanabe K; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, 525-8577, Japan.
Negoro R; Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, 525-8577, Japan. Electronic address: negoro-r@fc.ritsumei.ac.jp.
Fujita T; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, 525-8577, Japan; Laboratory of Molecular Pharmacokinetics, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, 525-8577, Japan; Research Center for Drug Discovery and Development, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, 525-8577, Japan.

Biochem Biophys Res Commun ; 664: 94-99, 2023 07 05.

Article em En | MEDLINE | ID: mdl-37141642

Assuntos

Ácido Aminolevulínico; Citocromo P-450 CYP3A; Humanos; Citocromo P-450 CYP3A/genética; Citocromo P-450 CYP3A/metabolismo; Células CACO-2; Ácido Aminolevulínico/farmacologia; Heme; Sistema Enzimático do Citocromo P-450/metabolismo

Palavras-chave

5-ALA; CYP3A4; Caco-2 cell; Drug-metabolizing enzyme

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocromo P-450 CYP3A / Ácido Aminolevulínico Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

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