Discovery of [5,5'-bibenzo[d][1,3]dioxol]-6-substituted amine derivatives as potent proprotein convertase subtilisin/kexin type 9 inhibitors.

Zhu, Dongqi; Qin, Hongyu; Wang, Xiaojing; Jia, Yuping; Wang, Xuejian; Zhang, Lei

Zhu, Dongqi; Qin, Hongyu; Wang, Xiaojing; Jia, Yuping; Wang, Xuejian; Zhang, Lei.

Afiliação

Zhu D; Department of Pharmacology, School of Pharmacy, Weifang Medical University, Weifang, China.
Qin H; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
Wang X; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.
Jia Y; Shandong Academy of Pharmaceutical Science, Jinan, China.
Wang X; Department of Pharmacology, School of Pharmacy, Weifang Medical University, Weifang, China.
Zhang L; Department of Medicinal Chemistry, School of Pharmacy, Weifang Medical University, Weifang, China.

Chem Biol Drug Des ; 102(1): 153-167, 2023 07.

Article em En | MEDLINE | ID: mdl-37170061

Assuntos

Hiperlipidemias; Pró-Proteína Convertase 9; Humanos; Pró-Proteína Convertase 9/química; Receptores de LDL/metabolismo; Simulação de Acoplamento Molecular; Células Hep G2; Hiperlipidemias/tratamento farmacológico; Subtilisinas

Palavras-chave

LDLR; PCSK9; PPI inhibitor; hyperlipidemia; structural modification

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Proteína Convertase 9 / Hiperlipidemias Limite: Humans Idioma: En Revista: Chem Biol Drug Des Assunto da revista: BIOQUIMICA / FARMACIA / FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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