Genotype-Phenotype Models Predicting VÌO 2max Response to High-Intensity Interval Training in Physically Inactive Chinese.
Med Sci Sports Exerc
; 55(10): 1905-1912, 2023 10 01.
Article
em En
| MEDLINE
| ID: mdl-37170954
ABSTRACT
PURPOSE:
This study aimed to analyze the interindividual differences of the maximal oxygen uptake (VÌO 2max ) response to 12 wk of high-intensity interval training (HIIT), and the genotype-phenotype models were constructed to predict the effect of HIIT on VÌO 2max .METHODS:
A total of 228 physically inactive adults who completed a 12-wk HIIT were analyzed. A genome-wide association study (GWAS) was conducted to identify genetic variants associated with the VÌO 2max response. Nonresponders, responders, and the highest training responders were defined as the effect sizes (ES) <0.2, ≥0.2, and ≥0.8, respectively. We generated polygenic predictor score (PPS) using lead variants and constructed a predictive model for VÌO 2max response based on a linear stepwise regression analysis.RESULTS:
The VÌO 2max increased significantly after HIIT (~14%, P < 0.001), but with interindividual differences (-7.8 to 17.9 mL·kg -1 ·min -1 ). In 27% of participants, the VÌO 2max showed no improvement. We identified one genetic locus near the γ-aminobutyric acid type A receptor subunit beta 3 gene ( GABRB3 , rs17116985) associated with VÌO 2max response at the genome-wide significance level ( P < 5 × 10 -8 ), and an additional nine single nucleotide polymorphisms (SNPs) at the suggestive significance level ( P < 1 × 10 -5 ). The SNPs rs474377, rs9365605, and rs17116985, respectively, explained 11%, 9%, and 6.2% of variance in VÌO 2max response. The 13 SNPs ( P < 1 × 10 -5 ) were found on chromosome 6 (position 148209316-148223568). Individuals with a PPS greater than 1.757 had the highest response, and those with a PPS lower than -3.712 were nonresponders. The PPS, baseline VÌO 2max , sex, and body mass explained 56.4% of the variance in the VÌO 2max response; the major predictor was the PPS, which explained 39.4% of the variance.CONCLUSIONS:
The PPS, baseline VÌO 2max , sex, and body mass could explain the variance in VÌO 2max response. Individuals who had a PPS greater than 1.757 had the highest training response after 12 wk of HIIT. Genetic variants in a region on chromosome 6, especially the sterile alpha motif domain containing 5 gene ( SAMD5 ), which had been explored influencing angiogenesis, might have a potential role in the VÌO 2max response.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Treinamento Intervalado de Alta Intensidade
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Med Sci Sports Exerc
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China