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Responsiveness to Vedolizumab Therapy in Ulcerative Colitis is Associated With Alterations in Immune Cell-Cell Communications.
Hsu, Paul; Choi, Eunice J; Patel, Shefali A; Wong, William H; Olvera, Jocelyn G; Yao, Priscilla; Liu, Yi Chia; Tsai, Matthew S; Wang, Wei; Boland, Brigid S; Chang, John T.
Afiliação
  • Hsu P; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Choi EJ; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA.
  • Patel SA; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Wong WH; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Olvera JG; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Yao P; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Liu YC; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Tsai MS; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Wang W; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA.
  • Boland BS; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, USA.
  • Chang JT; Department of Medicine, University of California San Diego, La Jolla, California, USA.
Inflamm Bowel Dis ; 29(10): 1602-1612, 2023 10 03.
Article em En | MEDLINE | ID: mdl-37235748
Compared to ulcerative patients unresponsive to vedolizumab, immune cell networks of ulcerative colitis patients responsive to vedolizumab have decreased proportion of TH17 and less pro-inflammatory signaling in the gut. Decreased pro-TH17 and interleukin (IL)-1 signaling from classical monocytes and innate immunocytes may mediate this phenotype.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Colite Ulcerativa Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Inflamm Bowel Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Colite Ulcerativa Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Inflamm Bowel Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos