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Epigenetic aging in older breast cancer survivors and noncancer controls: preliminary findings from the Thinking and Living with Cancer Study.
Rentscher, Kelly E; Bethea, Traci N; Zhai, Wanting; Small, Brent J; Zhou, Xingtao; Ahles, Tim A; Ahn, Jaeil; Breen, Elizabeth C; Cohen, Harvey Jay; Extermann, Martine; Graham, Deena M A; Jim, Heather S L; McDonald, Brenna C; Nakamura, Zev M; Patel, Sunita K; Root, James C; Saykin, Andrew J; Van Dyk, Kathleen; Mandelblatt, Jeanne S; Carroll, Judith E.
Afiliação
  • Rentscher KE; Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Bethea TN; Norman Cousins Center for Psychoneuroimmunology, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.
  • Zhai W; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California, USA.
  • Small BJ; Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
  • Zhou X; Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
  • Ahles TA; School of Aging Studies, University of South Florida, Tampa, Florida, USA.
  • Ahn J; Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
  • Breen EC; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Cohen HJ; Department of Biostatistics, Bioinformatics, and Biomathematics, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
  • Extermann M; Norman Cousins Center for Psychoneuroimmunology, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.
  • Graham DMA; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California, USA.
  • Jim HSL; Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, USA.
  • McDonald BC; Moffitt Cancer Center, University of South Florida, Tampa, Florida, USA.
  • Nakamura ZM; John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey, USA.
  • Patel SK; Moffitt Cancer Center, University of South Florida, Tampa, Florida, USA.
  • Root JC; Department of Radiology and Imaging Sciences, Indiana University School of Medicine and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, USA.
  • Saykin AJ; Department of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
  • Van Dyk K; City of Hope National Medical Center, Los Angeles, California, USA.
  • Mandelblatt JS; Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Carroll JE; Department of Radiology and Imaging Sciences, Indiana University School of Medicine and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, USA.
Cancer ; 129(17): 2741-2753, 2023 09 01.
Article em En | MEDLINE | ID: mdl-37259669
ABSTRACT

BACKGROUND:

Cancer and its treatments may accelerate aging in survivors; however, research has not examined epigenetic markers of aging in longer term breast cancer survivors. This study examined whether older breast cancer survivors showed greater epigenetic aging than noncancer controls and whether epigenetic aging related to functional outcomes.

METHODS:

Nonmetastatic breast cancer survivors (n = 89) enrolled prior to systemic therapy and frequency-matched controls (n = 101) ages 62 to 84 years provided two blood samples to derive epigenetic aging measures (Horvath, Extrinsic Epigenetic Age [EEA], PhenoAge, GrimAge, Dunedin Pace of Aging) and completed cognitive (Functional Assessment of Cancer Therapy-Cognitive Function) and physical (Medical Outcomes Study Short Form-12) function assessments at approximately 24 to 36 and 60 months after enrollment. Mixed-effects models tested survivor-control differences in epigenetic aging, adjusting for age and comorbidities; models for functional outcomes also adjusted for racial group, site, and cognitive reserve.

RESULTS:

Survivors were 1.04 to 2.22 years biologically older than controls on Horvath, EEA, GrimAge, and DunedinPACE measures (p = .001-.04) at approximately 24 to 36 months after enrollment. Survivors exposed to chemotherapy were 1.97 to 2.71 years older (p = .001-.04), and among this group, an older EEA related to worse self-reported cognition (p = .047) relative to controls. An older epigenetic age related to worse physical function in all women (p < .001-.01). Survivors and controls showed similar epigenetic aging over time, but Black survivors showed accelerated aging over time relative to non-Hispanic White survivors.

CONCLUSION:

Older breast cancer survivors, particularly those exposed to chemotherapy, showed greater epigenetic aging than controls that may relate to worse outcomes. If replicated, measurement of biological aging could complement geriatric assessments to guide cancer care for older women.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Problema de saúde: 1_doencas_nao_transmissiveis / 2_muertes_prematuras_enfermedades_notrasmisibles Assunto principal: Neoplasias da Mama / Sobreviventes de Câncer Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged / Female / Humans / Infant Idioma: En Revista: Cancer Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Problema de saúde: 1_doencas_nao_transmissiveis / 2_muertes_prematuras_enfermedades_notrasmisibles Assunto principal: Neoplasias da Mama / Sobreviventes de Câncer Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged / Female / Humans / Infant Idioma: En Revista: Cancer Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos