Nicotine exacerbates atherosclerosis and plaque instability via NLRP3 inflammasome activation in vascular smooth muscle cells.

An, Junqing; Ouyang, Liu; Yu, Changjiang; Carr, Sean Michael; Ramprasath, Tharmarajan; Liu, Zhixue; Song, Ping; Zou, Ming-Hui; Ding, Ye

An, Junqing; Ouyang, Liu; Yu, Changjiang; Carr, Sean Michael; Ramprasath, Tharmarajan; Liu, Zhixue; Song, Ping; Zou, Ming-Hui; Ding, Ye.

Afiliação

An J; Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA.
Ouyang L; Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA.
Yu C; Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA.
Carr SM; Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA.
Ramprasath T; Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA.
Liu Z; Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA.
Song P; Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA.
Zou MH; Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA.
Ding Y; Center for Molecular and Translational Medicine, Georgia State University, 157 Decatur Street SE, Atlanta, GA 30303, USA.

Theranostics ; 13(9): 2825-2842, 2023.

Article em En | MEDLINE | ID: mdl-37284455

Assuntos

Aterosclerose; Placa Aterosclerótica; Animais; Camundongos; Inflamassomos/genética; Proteína 3 que Contém Domínio de Pirina da Família NLR/genética; Catepsina B; Nicotina/efeitos adversos; Músculo Liso Vascular; Aterosclerose/genética; Apolipoproteínas E/genética

Palavras-chave

NLRP3 inflammasome; Nicotine; VSMC; atherosclerosis; lysosomal dysfunction; unstable plaque

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aterosclerose / Placa Aterosclerótica Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Theranostics Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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