The effects of degree and duration of supersaturation on in vivo absorption profiles for highly permeable drugs, dipyridamole and ketoconazole.

Higashino, Haruki; Minami, Keiko; Takagi, Toshihide; Kataoka, Makoto; Yamashita, Shinji

Higashino, Haruki; Minami, Keiko; Takagi, Toshihide; Kataoka, Makoto; Yamashita, Shinji.

Afiliação

Higashino H; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan; Pharmaron (Exton) Lab Services LLC (Absorption Systems LLC), 436 Creamery way, Suite 600, Exton, PA 19341, USA. Electronic address: Haruki.Higashino@pharmaron.com.
Minami K; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
Takagi T; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
Kataoka M; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.
Yamashita S; Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan.

Eur J Pharm Biopharm ; 189: 48-55, 2023 Aug.

Article em En | MEDLINE | ID: mdl-37301301

Assuntos

Dipiridamol; Cetoconazol; Ratos; Animais; Cetoconazol/química; Preparações Farmacêuticas; Solubilidade

Palavras-chave

BCS Class II; Bioavailability; Liquid-liquid phase separation; Oral absorption; Precipitation; Supersaturation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dipiridamol / Cetoconazol Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Eur J Pharm Biopharm Assunto da revista: FARMACIA / FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article

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