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High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs.
Knezevic, Lea; Wachsmann, Tassilo L A; Francis, Ore; Dockree, Tamsin; Bridgeman, John S; Wouters, Anne; de Wet, Ben; Cole, David K; Clement, Mathew; McLaren, James E; Gostick, Emma; Ladell, Kristin; Llewellyn-Lacey, Sian; Price, David A; van den Berg, Hugo A; Tabi, Zsuzsanna; Sessions, Richard B; Heemskerk, Mirjam H M; Wooldridge, Linda.
Afiliação
  • Knezevic L; Faculty of Health Sciences, University of Bristol, Bristol, UK; Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: knezevic.lea@gmail.com.
  • Wachsmann TLA; Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands.
  • Francis O; Faculty of Health Sciences, University of Bristol, Bristol, UK.
  • Dockree T; Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK.
  • Bridgeman JS; Instil Bio Inc, Dallas, Texas, USA.
  • Wouters A; Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands.
  • de Wet B; Immunocore, Abingdon, UK.
  • Cole DK; Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK; Immunocore, Abingdon, UK.
  • Clement M; Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK; Systems Immunity Research Institute, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK.
  • McLaren JE; Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK.
  • Gostick E; Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK.
  • Ladell K; Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK.
  • Llewellyn-Lacey S; Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK.
  • Price DA; Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK; Systems Immunity Research Institute, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK.
  • van den Berg HA; Warwick Mathematics Institute, University of Warwick, Coventry, UK.
  • Tabi Z; Division of Infection and Immunity, Cardiff University School of Medicine, University Hospital of Wales, Cardiff, UK.
  • Sessions RB; Faculty of Life Sciences, University of Bristol, Bristol, UK.
  • Heemskerk MHM; Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands.
  • Wooldridge L; Faculty of Health Sciences, University of Bristol, Bristol, UK. Electronic address: linda.wooldridge@bristol.ac.uk.
J Biol Chem ; 299(8): 104981, 2023 08.
Article em En | MEDLINE | ID: mdl-37390984
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Antígenos de Histocompatibilidade Classe I / Antígenos CD8 / Linfócitos T CD8-Positivos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Antígenos de Histocompatibilidade Classe I / Antígenos CD8 / Linfócitos T CD8-Positivos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2023 Tipo de documento: Article