HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway.

Li, Bai-Yu; Peng, Wan-Qiu; Liu, Yang; Guo, Liang; Tang, Qi-Qun

Li, Bai-Yu; Peng, Wan-Qiu; Liu, Yang; Guo, Liang; Tang, Qi-Qun.

Afiliação

Li BY; Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Peng WQ; Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Liu Y; Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Guo L; School of Exercise and Health and Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China. Electronic address: guoliang@sus.edu.cn.
Tang QQ; Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: q

Cell Rep ; 42(7): 112731, 2023 07 25.

Article em En | MEDLINE | ID: mdl-37393616

Assuntos

NAD; Sirtuína 1; Animais; Camundongos; Adipócitos Marrons/metabolismo; Tecido Adiposo Marrom/metabolismo; Tecido Adiposo Branco/metabolismo; Dano ao DNA; Camundongos Endogâmicos C57BL; NAD/metabolismo; Obesidade/metabolismo; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Sirtuína 1/genética; Sirtuína 1/metabolismo; Termogênese/genética

Palavras-chave

CP: Metabolism; DNA damage; HIGD1A; NAD(+)/NADH ratio; ROS; SIRT1; adipocyte browning; hypoxia-induced gene domain protein-1a; sirtuin1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sirtuína 1 / NAD Limite: Animals Idioma: En Revista: Cell Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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