Fluoxetine partially alleviates inflammation in the kidney of socially stressed male C57 BL/6 mice.
FEBS Open Bio
; 13(9): 1723-1736, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37400956
ABSTRACT
Stress-related illnesses are linked to the onset and progression of renal diseases and depressive disorders. To investigate stress-induced changes in the renal transcriptome associated with the development of depressive behaviors, we generated here a chronic social defeat stress (CSDS) model of C57 BL/6 male mice and then performed RNA sequencing of the kidneys to obtain an inflammation-related transcriptome. Administration of the antidepressant drug fluoxetine (10 mg·kg-1 ·day-1 ) during CSDS induction could partially alleviate renal inflammation and reverse CSDS-induced depression-like behaviors. Moreover, fluoxetine also modulated gene expression of stress-related hormone receptors, including prolactin and melanin-concentrating hormone. These results suggest that CSDS can induce gene expression changes associated with inflammation in the kidney of C57 BL/6 male mice, and this inflammation can be treated effectively by fluoxetine.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fluoxetina
/
Antidepressivos
Limite:
Animals
Idioma:
En
Revista:
FEBS Open Bio
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China