ADAM12 promotes the resistance of lung adenocarcinoma cells to EGFR-TKI and regulates the immune microenvironment by activating PI3K/Akt/mTOR and RAS signaling pathways.

Li, Keyu; Quan, Lingli; Huang, Fang; Li, Yukun; Shen, Zhenyu

Li, Keyu; Quan, Lingli; Huang, Fang; Li, Yukun; Shen, Zhenyu.

Afiliação

Li K; Department of Respiratory and Critical Care Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine Central South University, Changsha 410008, China.
Quan L; Department of Pulmonary and Critical Care Medicine 1, The Affiliated Zhuzhou Hospital Xiangya Medical College CSU, Central South University, Zhuzhou 412000, China.
Huang F; Department of General Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine Central South University, Changsha 410008, China.
Li Y; Department of Assisted Reproductive Centre, The Affiliated Zhuzhou Hospital Xiangya Medical College CSU, Central South University, Zhuzhou 412000, China. Electronic address: Yukun_li@foxmail.com.
Shen Z; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hunan University of Medicine, Huaihua 418000, China. Electronic address: ZhenYuShen0701@126.com.

Int Immunopharmacol ; 122: 110580, 2023 Sep.

Article em En | MEDLINE | ID: mdl-37418984

Assuntos

Adenocarcinoma de Pulmão; Neoplasias Pulmonares; Humanos; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Neoplasias Pulmonares/patologia; Receptores ErbB/genética; Receptores ErbB/metabolismo; Resistencia a Medicamentos Antineoplásicos; Linhagem Celular Tumoral; Adenocarcinoma de Pulmão/tratamento farmacológico; Adenocarcinoma de Pulmão/genética; Adenocarcinoma de Pulmão/metabolismo; Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo; Proliferação de Células; Microambiente Tumoral; Proteína ADAM12/genética; Proteína ADAM12/metabolismo

Palavras-chave

ADAM12; Bioinformatic analysis; EGFR-TKI resistance; Immune microenvironment; Lung adenocarcinoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenocarcinoma de Pulmão / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int Immunopharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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