Your browser doesn't support javascript.
loading
Targeting hepatitis B vaccine escape using immunogenetics in Bangladeshi infants.
Butler-Laporte, Guillaume; Auckland, Kathryn; Noor, Zannatun; Kabir, Mamun; Alam, Masud; Carstensen, Tommy; Wojcik, Genevieve L; Chong, Amanda Y; Pomilla, Cristina; Noble, Janelle A; McDevitt, Shana L; Smits, Gaby; Wareing, Susan; van der Klis, Fiona Rm; Jeffery, Katie; Kirkpatrick, Beth D; Sirima, Sodiomon; Madhi, Shabir; Elliott, Alison; Richards, J Brent; Hill, Adrian Vs; Duggal, Priya; Sandhu, Manjinder S; Haque, Rashidul; Petri, William A; Mentzer, Alexander J.
Afiliação
  • Butler-Laporte G; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Auckland K; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
  • Noor Z; Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada.
  • Kabir M; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Alam M; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
  • Carstensen T; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
  • Wojcik GL; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
  • Chong AY; Wellcome Trust Sanger Institute, University of Cambridge, Hinxton, United Kingdom.
  • Pomilla C; Queen Mary University of London, London, United Kingdom.
  • Noble JA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • McDevitt SL; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
  • Smits G; Wellcome Trust Sanger Institute, University of Cambridge, Hinxton, United Kingdom.
  • Wareing S; Children's Hospital Oakland Research Institute, Oakland, California, USA.
  • van der Klis FR; Department of Pediatrics, University of California, San Francisco, California, USA.
  • Jeffery K; Media Labs, Inc. Alameda, CA, USA.
  • Kirkpatrick BD; National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Sirima S; Microbiology Department, John Radcliffe Hospital, Oxford University NHS Foundation Trust, Oxford, UK.
  • Madhi S; National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Elliott A; Microbiology Department, John Radcliffe Hospital, Oxford University NHS Foundation Trust, Oxford, UK.
  • Richards JB; Department of Microbiology and Molecular Genetics, Vaccine Testing Center, University of Vermont College of Medicine, Vermont, USA.
  • Hill AV; Groupe de Recherche Action en Santé (GRAS) 06 BP 10248 Ouagadougou, Burkina Faso.
  • Duggal P; South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
  • Sandhu MS; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
  • Haque R; Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
  • Petri WA; Department of Human Genetics, McGill University, Montréal, Québec, Canada.
  • Mentzer AJ; 5 Prime Sciences Inc, Montreal, Quebec, Canada.
medRxiv ; 2023 Jun 29.
Article em En | MEDLINE | ID: mdl-37425840
ABSTRACT
Hepatitis B virus (HBV) vaccine escape mutants (VEM) are increasingly described, threatening progress in control of this virus worldwide. Here we studied the relationship between host genetic variation, vaccine immunogenicity and viral sequences implicating VEM emergence. In a cohort of 1,096 Bangladeshi children, we identified human leukocyte antigen (HLA) variants associated with response vaccine antigens. Using an HLA imputation panel with 9,448 south Asian individuals DPB1*0401 was associated with higher HBV antibody responses (p=4.5×10-30). The underlying mechanism is a result of higher affinity binding of HBV surface antigen epitopes to DPB1*0401 dimers. This is likely a result of evolutionary pressure at the HBV surface antigen 'a-determinant' segment incurring VEM specific to HBV. Prioritizing pre-S isoform HBV vaccines may tackle the rise of HBV vaccine evasion.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Problema de saúde: 1_doencas_transmissiveis / 2_enfermedades_transmissibles Idioma: En Revista: MedRxiv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Problema de saúde: 1_doencas_transmissiveis / 2_enfermedades_transmissibles Idioma: En Revista: MedRxiv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido