Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women.
Br J Cancer
; 129(7): 1119-1125, 2023 10.
Article
em En
| MEDLINE
| ID: mdl-37537254
ABSTRACT
BACKGROUND:
An association was observed between an inflammation-related risk score (IRRS) and worse overall survival (OS) among a cohort of mostly White women with invasive epithelial ovarian cancer (EOC). Herein, we evaluated the association between the IRRS and OS among Black women with EOC, a population with higher frequencies of pro-inflammatory exposures and worse survival.METHODS:
The analysis included 592 Black women diagnosed with EOC from the African American Cancer Epidemiology Study (AACES). Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of the IRRS and OS, adjusting for relevant covariates. Additional inflammation-related exposures, including the energy-adjusted Dietary Inflammatory Index (E-DIITM), were evaluated.RESULTS:
A dose-response trend was observed showing higher IRRS was associated with worse OS (per quartile HR 1.11, 95% CI 1.01-1.22). Adding the E-DII to the model attenuated the association of IRRS with OS, and increasing E-DII, indicating a more pro-inflammatory diet, was associated with shorter OS (per quartile HR 1.12, 95% CI 1.02-1.24). Scoring high on both indices was associated with shorter OS (HR 1.54, 95% CI 1.16-2.06).CONCLUSION:
Higher levels of inflammation-related exposures were associated with decreased EOC OS among Black women.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Inflamação
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
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Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Br J Cancer
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos