Selective inhibition of hsp90 paralogs: Structure and binding studies uncover the role of helix 1 in Grp94-selective ligand binding.

Que, Nanette L S; Seidler, Paul M; Aw, Wen J; Chiosis, Gabriela; Gewirth, Daniel T

Que, Nanette L S; Seidler, Paul M; Aw, Wen J; Chiosis, Gabriela; Gewirth, Daniel T.

Afiliação

Que NLS; Hauptman Woodward Medical Research Institute, Buffalo, NY 14203.
Seidler PM; Hauptman Woodward Medical Research Institute, Buffalo, NY 14203.
Aw WJ; Hauptman Woodward Medical Research Institute, Buffalo, NY 14203.
Chiosis G; Chemical Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.
Gewirth DT; Hauptman Woodward Medical Research Institute, Buffalo, NY 14203.

bioRxiv ; 2023 Aug 01.

Article em En | MEDLINE | ID: mdl-37577523

Palavras-chave

Grp94; Hsp90; PU-H36; PU-H71; chaperone

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2023 Tipo de documento: Article