Harnessing the dual antimicrobial mode of action with a lipophilic Mn(II) complex using the principle of the Irving-Williams Series to completely eradicate Staphylococcus aurous.
Dalton Trans
; 52(35): 12203-12207, 2023 Sep 13.
Article
em En
| MEDLINE
| ID: mdl-37609944
ABSTRACT
The judicious selection of 5,7-dibromo-2-methy-8-quinolinol (BQ) as a Mn(II) ionophore results in the synthesis of Mn(BQ)2(DMSO)2·DMSO (1), a potent metalloantibiotic with a dual antimicrobial mode of action against four different strains of Staphylococcus aurous (SA) bacteria (MIC = 0.625 µg mL-1). Additionally, 1 can overcome ciprofloxacin-resistance in methicillin-resistant SA bacteria.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dimetil Sulfóxido
/
Anti-Infecciosos
Idioma:
En
Revista:
Dalton Trans
Assunto da revista:
QUIMICA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos