Development of the early-life gut microbiome and associations with eczema in a prospective Chinese cohort.
mSystems
; 8(5): e0052123, 2023 Oct 26.
Article
em En
| MEDLINE
| ID: mdl-37646516
ABSTRACT
IMPORTANCE Eczema is a major allergic disease in children, which is particularly prevalent in Chinese children during their first year of life. In this study, we showed that alterations in the infant gut microbiota precede the development of eczema in a prospective Chinese cohort. In particular, we discovered enrichments of the genera Clostridium sensu stricto 1 and Finegoldia in the cases at 3 and 1 month of age, respectively, which may represent potential targets for intervention to prevent eczema. Besides, we identified a depletion of Bacteroides from 1 to 6 months of age and an enrichment of Clostridium sensu stricto 1 at 3 months in the eczema cases, patterns also observed in C-section-born infants within the same time frames, providing first evidence to support a role of the gut microbiota in previously reported associations between C-section and increased risk of eczema in infancy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
3_ND
Problema de saúde:
3_zoonosis
Assunto principal:
Eczema
/
Microbioma Gastrointestinal
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Female
/
Humans
/
Infant
/
Pregnancy
País/Região como assunto:
Asia
Idioma:
En
Revista:
MSystems
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China