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Genomic analyses reveal a low-temperature adapted clade in Halorubrum, a widespread haloarchaeon across global hypersaline environments.
Chen, Liangzhong; Hong, Tao; Wu, Zirui; Song, Weizhi; Chen, Shaoxing X; Liu, Yongqin; Shen, Liang.
Afiliação
  • Chen L; College of Life Sciences, Anhui Normal University, Wuhu, 241000, China.
  • Hong T; Anhui Provincial Key Laboratory of Conservation and Exploitation of Biological Resources, Anhui Normal University, Wuhu, 241000, China.
  • Wu Z; Anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Diseases, and Auhui Provincial Engineering Research Centre for Molecular Detection and Diagnostics, Anhui Normal University, Wuhu, 241000, China.
  • Song W; College of Life Sciences, Anhui Normal University, Wuhu, 241000, China.
  • Chen SX; College of Life Sciences, Anhui Normal University, Wuhu, 241000, China.
  • Liu Y; Centre for Marine Bio-Innovation, University of New South Wales, Sydney, NSW, 2052, Australia.
  • Shen L; College of Life Sciences, Anhui Normal University, Wuhu, 241000, China. chensx@ahnu.edu.cn.
BMC Genomics ; 24(1): 508, 2023 Aug 31.
Article em En | MEDLINE | ID: mdl-37653415
ABSTRACT

BACKGROUND:

Cold-adapted archaea have diverse ecological roles in a wide range of low-temperature environments. Improving our knowledge of the genomic features that enable psychrophiles to grow in cold environments helps us to understand their adaptive responses. However, samples from typical cold regions such as the remote Arctic and Antarctic are rare, and the limited number of high-quality genomes available leaves us with little data on genomic traits that are statistically associated with cold environmental conditions.

RESULTS:

In this study, we examined the haloarchaeal genus Halorubrum and defined a new clade that represents six isolates from polar and deep earth environments ('PD group' hereafter). The genomic G + C content and amino acid composition of this group distinguishes it from other Halorubrum and the trends are consistent with the established genomic optimization of psychrophiles. The cold adaptation of the PD group was further supported by observations of increased flexibility of proteins encoded across the genome and the findings of a growth test.

CONCLUSIONS:

The PD group Halorubrum exhibited denser genome packing, which confers higher metabolic potential with constant genome size, relative to the reference group, resulting in significant differences in carbon, nitrogen and sulfur metabolic patterns. The most marked feature was the enrichment of genes involved in sulfur cycling, especially the production of sulfite from organic sulfur-containing compounds. Our study provides an updated view of the genomic traits and metabolic potential of Halorubrum and expands the range of sources of cold-adapted haloarchaea.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Halorubrum Idioma: En Revista: BMC Genomics Assunto da revista: GENETICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Halorubrum Idioma: En Revista: BMC Genomics Assunto da revista: GENETICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
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