Keverprazan, a novel potassium-competitive acid blocker: Single ascending dose safety, tolerability, pharmacokinetics, pharmacodynamics and food effect in healthy subjects.

Zhou, Sufeng; Xie, Lijun; Zhou, Chen; Zhao, Yuqing; Wang, Lu; Ding, Sijia; Chen, Juan; Zhu, Bei; Su, Mei; Shao, Feng

Zhou, Sufeng; Xie, Lijun; Zhou, Chen; Zhao, Yuqing; Wang, Lu; Ding, Sijia; Chen, Juan; Zhu, Bei; Su, Mei; Shao, Feng.

Afiliação

Zhou S; Phase I Clinical Trial Unit, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Xie L; Phase I Clinical Trial Unit, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Zhou C; Phase I Clinical Trial Unit, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Zhao Y; Phase I Clinical Trial Unit, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Wang L; Phase I Clinical Trial Unit, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Ding S; Phase I Clinical Trial Unit, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Chen J; Phase I Clinical Trial Unit, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Zhu B; Phase I Clinical Trial Unit, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
Su M; Jiangsu Carephar Pharmaceutical Co., Ltd, Nanjing 210000, China. Electronic address: sumei@carephar.com.
Shao F; Phase I Clinical Trial Unit, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China; Department of Clinical Pharmacology, Pharmacy College, Nanjing Medical University, Nanjing 211166, China. Electronic address: jsphshaofeng@hotmail.com.

Eur J Pharm Sci ; 190: 106578, 2023 Nov 01.

Article em En | MEDLINE | ID: mdl-37666458

Palavras-chave

Gastroesophageal reflux disease; Keverprazan; Peptic ulcer; Pharmacodynamics; Pharmacokinetics; Potassium-competitive acid blocker

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_zoonosis Tipo de estudo: Clinical_trials Idioma: En Revista: Eur J Pharm Sci Assunto da revista: FARMACIA / FARMACOLOGIA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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