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Fluorescence-guided photoimmunotherapy using targeted nanotechnology and ML7710 to manage peritoneal carcinomatosis.
Liang, Barry J; Pang, Sumiao; Perttila, Robert; Ma, Chen-Hua; Srivastava, Payal; Gaitan, Brandon; Sorrin, Aaron J; Fadul, Nada; Rahman, Idrisa; Yl Formula See Text Niemi, Zoe; Roque, Dana M; Hasan, Tayyaba; Uusimaa, Petteri; Huang, Huang-Chiao.
Afiliação
  • Liang BJ; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
  • Pang S; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Perttila R; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
  • Ma CH; Modulight Corporation, Tampere, Finland.
  • Srivastava P; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
  • Gaitan B; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
  • Sorrin AJ; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
  • Fadul N; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
  • Rahman I; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
  • Yl Formula See Text Niemi Z; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
  • Roque DM; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  • Hasan T; Modulight Corporation, Tampere, Finland.
  • Uusimaa P; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Huang HC; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Sci Adv ; 9(36): eadi3441, 2023 09 08.
Article em En | MEDLINE | ID: mdl-37672582
ABSTRACT
Fluorescence-guided intervention can bolster standard therapies by detecting and treating microscopic tumors before lethal recurrence. Tremendous progress in photoimmunotherapy and nanotechnology has been made to treat metastasis. However, many are lost in translation due to heterogeneous treatment effects. Here, we integrate three technological advances in targeted photo-activable multi-agent liposome (TPMAL), fluorescence-guided intervention, and laser endoscopy (ML7710) to improve photoimmunotherapy. TPMAL consists of a nanoliposome chemotherapy labeled with fluorophores for tracking and photosensitizer immunoconjugates for photoimmunotherapy. ML7710 is connected to Modulight Cloud to capture and analyze multispectral emission from TPMAL for fluorescence-guided drug delivery (FGDD) and fluorescence-guided light dosimetry (FGLD) in peritoneal carcinomatosis mouse models. FGDD revealed that TPMAL enhances drug delivery to metastases by 14-fold. ML7710 captured interpatient variability in TPMAL uptake and prompted FGLD in >50% of animals. By combining TPMAL, ML7710, and fluorescence-guided intervention, variation in treatment response was substantially reduced and tumor control improved without side effects.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Peritoneais Limite: Animals Idioma: En Revista: Sci Adv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Peritoneais Limite: Animals Idioma: En Revista: Sci Adv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos