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Daily fosfomycin versus levofloxacin for complicated urinary tract infections.
Rouphael, Nadine; Winokur, Patricia; Keefer, Michael C; Traenkner, Jessica; Drobeniuc, Ana; Doi, Yohei; Munsiff, Sonal; Fowler, Vance G; Evans, Scott; Oler, Randolph E; Tuyishimire, Bonifride; Lee, Marina; Ghazaryan, Varduhi; Chambers, Henry F.
Afiliação
  • Rouphael N; Emory University School of Medicine , Atlanta, Georgia, USA.
  • Winokur P; Division of Infectious Diseases, Department of Internal Medicine, University of Iowa College of Medicine , Iowa City, Iowa, USA.
  • Keefer MC; Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York, USA.
  • Traenkner J; Emory University School of Medicine , Atlanta, Georgia, USA.
  • Drobeniuc A; Emory University School of Medicine , Atlanta, Georgia, USA.
  • Doi Y; University of Pittsburgh , Pittsburgh, Pennsylvania, USA.
  • Munsiff S; Antibacterial Resistance Leadership Group, Duke University Medical Center , Durham, North Carolina, USA.
  • Fowler VG; Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry , Rochester, New York, USA.
  • Evans S; Antibacterial Resistance Leadership Group, Duke University Medical Center , Durham, North Carolina, USA.
  • Oler RE; Division of Infectious Diseases, Department of Medicine, Duke University Medical Center , Durham, North Carolina, USA.
  • Tuyishimire B; Antibacterial Resistance Leadership Group, Duke University Medical Center , Durham, North Carolina, USA.
  • Lee M; George Washington University , Rockville, Maryland, USA.
  • Ghazaryan V; The Emmes Company, LLC , Rockville, Maryland, USA.
  • Chambers HF; The Emmes Company, LLC , Rockville, Maryland, USA.
mBio ; 14(5): e0167723, 2023 Oct 31.
Article em En | MEDLINE | ID: mdl-37698412
ABSTRACT
IMPORTANCE Concerns over resistance and safety have been identified in the current treatment regimen for complicated urinary tract infections. Fosfomycin is a drug that is routinely used for the treatment of uncomplicated cystitis. This study shows that fosfomycin could be an oral alternative as step-down therapy for the treatment of complicated urinary tract infections, with a clinical cure rate comparable to levofloxacin but a lower microbiological success rate 3 weeks from start of antibiotics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Urinárias / Cistite / Fosfomicina Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: MBio Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Urinárias / Cistite / Fosfomicina Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: MBio Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos