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De novo design of highly selective miniprotein inhibitors of integrins αvß6 and αvß8.
Roy, Anindya; Shi, Lei; Chang, Ashley; Dong, Xianchi; Fernandez, Andres; Kraft, John C; Li, Jing; Le, Viet Q; Winegar, Rebecca Viazzo; Cherf, Gerald Maxwell; Slocum, Dean; Poulson, P Daniel; Casper, Garrett E; Vallecillo-Zúniga, Mary L; Valdoz, Jonard Corpuz; Miranda, Marcos C; Bai, Hua; Kipnis, Yakov; Olshefsky, Audrey; Priya, Tanu; Carter, Lauren; Ravichandran, Rashmi; Chow, Cameron M; Johnson, Max R; Cheng, Suna; Smith, McKaela; Overed-Sayer, Catherine; Finch, Donna K; Lowe, David; Bera, Asim K; Matute-Bello, Gustavo; Birkland, Timothy P; DiMaio, Frank; Raghu, Ganesh; Cochran, Jennifer R; Stewart, Lance J; Campbell, Melody G; Van Ry, Pam M; Springer, Timothy; Baker, David.
Afiliação
  • Roy A; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Shi L; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Chang A; Encodia Inc, 5785 Oberlin Drive, San Diego, CA, 92121, USA.
  • Dong X; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA.
  • Fernandez A; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA.
  • Kraft JC; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
  • Li J; Engineering Research Center of Protein and Peptide Medicine, Ministry of Education, Nanjing, China.
  • Le VQ; Division of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
  • Winegar RV; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Cherf GM; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA.
  • Slocum D; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA.
  • Poulson PD; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA.
  • Casper GE; Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.
  • Vallecillo-Zúniga ML; Denali Therapeutics, South San Francisco, CA, USA.
  • Valdoz JC; Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, USA.
  • Miranda MC; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA.
  • Bai H; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA.
  • Kipnis Y; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA.
  • Olshefsky A; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT, 84602, USA.
  • Priya T; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Carter L; Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
  • Ravichandran R; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Chow CM; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Johnson MR; Howard Hughes Medical Institute, University of Washington, Seattle, WA, 98195, USA.
  • Cheng S; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Smith M; Department of Bioengineering, University of Washington, Seattle, WA, 98195, USA.
  • Overed-Sayer C; Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.
  • Finch DK; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
  • Lowe D; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Bera AK; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Matute-Bello G; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Birkland TP; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • DiMaio F; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Raghu G; Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, WA, 98195, USA.
  • Cochran JR; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Stewart LJ; Bioscience COPD/IPF, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Campbell MG; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Van Ry PM; Alchemab Therapeutics Ltd, Cambridge, UK.
  • Springer T; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Baker D; Evox Therapeutics Limited, Oxford Science Park, Medawar Centre, East Building, Robert Robinson Avenue, Oxford, OX4 4HG, England.
Nat Commun ; 14(1): 5660, 2023 09 13.
Article em En | MEDLINE | ID: mdl-37704610
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Integrinas Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Integrinas Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos