Comparative genomics of the T cell receptor µ locus in marsupials and monotremes.
Immunogenetics
; 75(6): 507-515, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37747540
ABSTRACT
T cells are a primary component of the vertebrate adaptive immune system. There are three mammalian T cell lineages based on their T cell receptors (TCR). The αß T cells and γδ T cells are ancient and found broadly in vertebrates. The more recently discovered γµ T cells are uniquely mammalian and only found in marsupials and monotremes. In this study, we compare the TCRµ locus (TRM) across the genomes of two marsupials, the gray short-tailed opossum and Tasmanian devil, and one monotreme, the platypus. These analyses revealed lineage-specific duplications, common to all non-eutherian mammals described. There is conserved synteny in the TRM loci of both marsupials but not in the monotreme. Our results are consistent with an ancestral cluster organization which was present in the last common mammalian ancestor which underwent lineage-specific duplications and divergence among the non-eutherian mammals.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ornitorrinco
/
Marsupiais
Limite:
Animals
Idioma:
En
Revista:
Immunogenetics
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos