Visible-light optical coherence tomography platform for the characterization of the skin barrier.
Biomed Opt Express
; 14(8): 3914-3923, 2023 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-37799680
ABSTRACT
We demonstrate a free-space, trolley-mountable Fourier domain visible-light optical coherence tomography (OCT) system for studying the stratum corneum in non-palmar human skin. An axial resolution of 1 µm in tissue and at least -75â
dB sensitivity have been achieved. High-quality B-scans, containing 1600 A-scans, are acquired at a rate of 39â
Hz. Images from the dorsal hand, ventral wrist and ventral forearm areas are obtained, with a clearly resolved stratum corneum layer (typically 5-15 µm thick) presenting as a hypoechogenic dark layer below the bright entrance signal, similar to that found in palmar skin with traditional OCT systems. We find that the appearance of the stratum corneum layer strongly depends on its water content, becoming brighter after occlusive hydration.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Biomed Opt Express
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Reino Unido