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Safety, tolerability, pharmacokinetics, and immunological activity of dual-combinations and triple-combinations of anti-HIV monoclonal antibodies PGT121, PGDM1400, 10-1074, and VRC07-523LS administered intravenously to HIV-uninfected adults: a phase 1 randomised trial.
Sobieszczyk, Magdalena E; Mannheimer, Sharon; Paez, Carmen A; Yu, Chenchen; Gamble, Theresa; Theodore, Deborah A; Chege, Wairimu; Yacovone, Margaret; Hanscom, Brett; Heptinstall, Jack; Seaton, Kelly E; Zhang, Lily; Miner, Maurine D; Eaton, Amanda; Weiner, Joshua A; Mayer, Kenneth; Kalams, Spyros; Stephenson, Kathryn; Julg, Boris; Caskey, Marina; Nussenzweig, Michel; Gama, Lucio; Barouch, Dan H; Ackerman, Margaret E; Tomaras, Georgia D; Huang, Yunda; Montefiori, David.
Afiliação
  • Sobieszczyk ME; Columbia University Irving Medical Center, New York, NY, USA. Electronic address: mes52@cumc.columbia.edu.
  • Mannheimer S; Mailman School of Public Health, Columbia University, New York, NY, USA.
  • Paez CA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Yu C; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Gamble T; FHI 360, Durham, NC, USA.
  • Theodore DA; Columbia University Irving Medical Center, New York, NY, USA.
  • Chege W; National Institute of Allergy and Infectious Diseases, Rockville, MD, USA.
  • Yacovone M; National Institute of Allergy and Infectious Diseases, Rockville, MD, USA.
  • Hanscom B; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Heptinstall J; Duke University School of Medicine, Durham, NC, USA.
  • Seaton KE; Duke University School of Medicine, Durham, NC, USA.
  • Zhang L; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Miner MD; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Eaton A; Duke University School of Medicine, Durham, NC, USA.
  • Weiner JA; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.
  • Mayer K; Fenway Institute, Boston, MA, USA.
  • Kalams S; Vanderbilt University Medical Center, Nashville, TN, USA.
  • Stephenson K; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Julg B; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Caskey M; Rockefeller University, New York, NY, USA.
  • Nussenzweig M; Rockefeller University, New York, NY, USA.
  • Gama L; Vaccine Research Center, National Institute of Health, Bethesda, MD, USA.
  • Barouch DH; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
  • Ackerman ME; Thayer School of Engineering, Dartmouth College, Hanover, NH, USA.
  • Tomaras GD; Duke University School of Medicine, Durham, NC, USA.
  • Huang Y; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
  • Montefiori D; Duke University School of Medicine, Durham, NC, USA.
Lancet HIV ; 10(10): e653-e662, 2023 10.
Article em En | MEDLINE | ID: mdl-37802566
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Problema de saúde: 1_doencas_nao_transmissiveis / 2_enfermedades_transmissibles Assunto principal: Infecções por HIV / HIV-1 Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet HIV Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Problema de saúde: 1_doencas_nao_transmissiveis / 2_enfermedades_transmissibles Assunto principal: Infecções por HIV / HIV-1 Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet HIV Ano de publicação: 2023 Tipo de documento: Article