Urinary stem cell-derived exocrine circRNA ATG7 regulates the SOCS1/STAT3 signaling pathway through miR-4500, inhibits M1 macrophage polarization, and alleviates the progression of diabetes nephropathy.

Sun, Yang; Zhao, Yanhong; Lu, Yongxin; Li, Hongmei; Xiang, Jin; Yang, Dongmei; Wang, Jinrui; Gao, Xinglian; Wang, Yian

Sun, Yang; Zhao, Yanhong; Lu, Yongxin; Li, Hongmei; Xiang, Jin; Yang, Dongmei; Wang, Jinrui; Gao, Xinglian; Wang, Yian.

Afiliação

Sun Y; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Zhao Y; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Lu Y; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Li H; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Xiang J; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Yang D; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Wang J; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Gao X; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China.
Wang Y; Kidney Internal Medicine, The Sixth Affiliated Hospital of Kunming Medical University, Yuxi, 653100, Yunnan, China. wangyian@kmmu.edu.cn.

Int Urol Nephrol ; 56(4): 1449-1463, 2024 Apr.

Article em En | MEDLINE | ID: mdl-37815664

Assuntos

Diabetes Mellitus; Nefropatias Diabéticas; Exossomos; MicroRNAs; Animais; Humanos; Ratos; Diabetes Mellitus/metabolismo; Nefropatias Diabéticas/metabolismo; Exossomos/metabolismo; Macrófagos; MicroRNAs/genética; RNA Circular/genética; RNA Circular/metabolismo; RNA Circular/farmacologia; Transdução de Sinais; Fator de Transcrição STAT3; Células-Tronco/metabolismo; Proteína 1 Supressora da Sinalização de Citocina/genética; Proteína 1 Supressora da Sinalização de Citocina/metabolismo; Proteína 1 Supressora da Sinalização de Citocina/farmacologia

Palavras-chave

CircRNA ATG7; Diabetes nephropathy; Macrophage; Urogenic stem cells; miR-4500

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Diabetes Mellitus / Nefropatias Diabéticas / Exossomos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Int Urol Nephrol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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